GTMN is for Detoxification
Maintaining healthy cells in our body is an ongoing challenge for our bodies. Our cells are continuously damaged by all kinds of endogenous (meaning - produced in the body) free radicals, reactive oxygen species,superoxide anions, carbon radicals and many other similar types of molecules. Our cells are also being continuously damaged by exogenous (meaning – from the outside) intrusions like chemical toxicants, heavy metals, pesticides, bacteria and viruses, microplastics, alcohol and other environmental insults.
Glutathione is the “master antioxidant” whose job it is in the body to detoxify all these inside and outside threats, which then allows for the repair of damaged cells. Repairing damaged cells leads to healthy cells, and this in turn leads to longevity and healthy aging. The crucial role of glutathione in scavenging for oxidants plus the loss of glutathione in the body due to disease and exposure to environmental factors makes glutathione the most sought-after detox agent in the world. GTMS’s glutathione is truly a master detox agent.
Furthermore, glutathione is a peptide – and is the safest, naturally occurring peptide around. Taking glutathione means you are taking a real peptide. Peptides are currently one of the hottest, most buzzed-about trends in health, fitness, and skincare, often described as a critical source of biohacking, anti-aging, and regenerative medicine.
Our GTMN is the result of expert aging and deep peptide science. GTMN only contains GSH, the reduced form of L-glutathione, the natural form, which is the ONLY form you should take, and is 99%+ pure. Our GTMN encapsulates glutathione with delayed release vegan capsules which are clinically proven to resist stomach acids for targeted absorption in the small intestine and for maximum bioavailability. This is ultracritical – traditional oral capsules are less effective because stomach enzymes can break down glutathione before it reaches the bloodstream. This means we have by far the best glutathione product available. GTMN is proudly manufactured in the USA and sold exclusively in the USA. Every batch is third-party tested to ensure professional grade quality and purity. Our packaging includes BPA free ultraviolet glass for superior preservation, as well as FSC mix box material and soy-based inks to help protect forests and promote sustainable practices in the packaging industry.
The science of healthy aging clear: Cell health = Your health.
Take one (1) capsule daily, without food in the morning, or as directed by your healthcare professional. Consult your healthcare professional before taking any dietary supplement, if you are pregnant, nursing, or taking any medication. Keep out of reach of children.
Store in a cool, dry place away from direct sunlight. Do not use if tamper-evident packaging is broken or missing.
L-Glutathione is the Master Detoxifier*
GTMN’s reduced L-glutathione is a scientifically proven master detoxifier and master antioxidant. (2) It is a peptide known for its antioxidant powers which continuously scavenges and neutralizes endogenous (meaning - inside the body) and exogenous (meaning – foreign introduced) challenges so that your cells can be detoxified, repaired and maintain their healthy function. This leads to the pot at the end of the rainbow - healthy aging and increased healthspan. Here we will examine the science behind these massive claims.
L-Glutathione is the Master Antioxidant. Before we get into the antioxidant properties of L-Glutathione, it’s important to know that there are two forms of L-Glutathione – the reduced state (GSH) and the oxidized state (GSSG). These two initials are used by chemists who understand the molecular structures of the two forms. The ratio of GSH to GSSG determines the redox (oxidative-reductive) status of cells. Healthy cells at rest have a GSH/GSSG ratio >100 while the ratio drops to 1 to 10 in cells exposed to oxidant stress. (1) This means that the reduced form GSH is the most potent form of L-Glutathione, so we can use these two terms interchangeably for its antioxidant properties. We only use the reduced form (GSH).
GSH serves as a cornerstone of cellular antioxidant defense, neutralizing reactive oxygen species (ROS), superoxide anion, hydroxyl radical, nitric oxide, and carbon radicals. GSH also catalytically detoxifies and oxidizes hydroperoxides, peroxynitrites, and lipid peroxides. (3) It acts as a cofactor for enzymes, such as glutathione peroxidase (GSHPx), which converts hydrogen peroxide into water. (4) Its ability to scavenge free radicals and protect biological membranes from lipid peroxidation underscores its protective role in oxidative stress. (5) GSH also protects cells from oxidants through the recycling of vitamins C and E. (6) This recycling regenerates these vitamins making them reusable as additional antioxidants. All these oxidative activities make GSH a true Master Antioxidant which neutralizes all these reactive oxidative species that are produced inside the body in every cell.
L-Glutathione Detoxifies External Threats
In addition to its antioxidant properties, GSH detoxifies xenobiotics, heavy metals, chemical toxicants, viruses and bacteria, alcohol, microplastics, smoke, pollutants, pesticides, and electrophilic compounds by conjugation (meaning - attaching to them), facilitating their excretion from the body. (7) GSH facilitates the plasma membrane transport of toxins by at least 4 different mechanisms, the most important of which is formation of glutathione S-conjugates. (1) In the liver, GSH binds to these toxins, converting them into water-soluble compounds for excretion. GSH also facilitates the transport of mercury out of the brain. (1) All these foreign toxicants and particles insult the body and damage cells and cellular DNA. GSH is able to detoxify the body by getting rid of all these foreign particles and external threats.
The L-Glutathione Detox Difference
This dual functionality (endogenous and exogenous detoxification) makes GSH a critical player in maintaining cellular health. This dual function is unique in the detoxification world, and is the first step to healthy cells, cellular and DNA repair, leading to increased healthspan and health aging.
L-Glutathione Levels in the Body are Lower with Disease
In another indication of the importance of GSH, low levels of glutathione are associated with AIDS/HIV, macular degeneration, Parkinson’s disease, neurodegenerative disorders, cardiovascular disease and loss of immune function. (1) This association does not suggest that GSH can prevent or cure these diseases; however it helps us understand the importance of taking GHS for healthy cellular and metabolic function. Exercise performance studies further illustrate GSH’s pharmacological versatility. GSH supplementation has been shown to improve lipid metabolism and reduce muscle acidification during exercise. (8) Conversely, high doses of LSD1 inhibitors depleted GSH in natural killer (NK) cells, impairing their function; this effect is reversed by GSH supplementation. (9) These findings highlight GSH’s context-dependent effects ranging from metabolic enhancement to immune modulation. Perhaps the best indicator of the importance of GSH is that its cellular and mitochondrial levels are highly associated with health and longevity. (1)
Safety and Toxicity of L-Glutathione
GSH supplementation is generally safe and GSH has a very low toxicity profile. Oral acute toxicity studies have reported an LD50 (a measure of toxicity) exceeding 5 g/kg (equivalent to >350 g in a 70 kg (154 lb person), indicating a substantial safety margin (this is > x 1,000 our dose). (10) Human trials have reported no serious adverse effects, even with prolonged use. (11, 12) Overall, GSH’s endogenous (in the body) production, as well as the biocompatibility of GSH (supplemented), reinforces its safety for supplementation.
L-Glutathione in Mitochondrial Health, Aging, and Neuroprotection
GSH is critical for mitochondrial health, protection against reactive oxygen species (ROS), and supporting energy production. SLC25A39 has been identified as a key regulator of mitochondrial GSH transport, which is essential for cellular proliferation. (13) In aging, GlyNAC supplementation increased the mouse lifespan by 24%, correcting GSH deficiency and mitochondrial dysfunction. (14) Neuroprotection studies have shown GSH’s ability to reduce oxidative neuronal damage, while the addition of NAC supplementation improved cognition, suggesting GSH’s role in combating cognitive decline.* (15, 16)
L-Glutathione in Immune Function and Athletic Recovery
GSH enhances immune function by supporting lymphocyte activity and cytokine production.* (17) Supplementation of GSH in immunocompromised populations has immune-boosting effects.* (12, 18) Additionally, reduced muscle fatigue and improved aerobic metabolism were observed with GSH supplementation in healthy athletes, highlighting its additional role in mitigating exercise-induced oxidative stress and enhancing recovery. (8, 19)
*This scientific review has not been evaluated by the Food and Drug Administration, and therefore the information contained herein is not intended to diagnose, treat, cure, or prevent any disease.
References
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2. Wu, G., Yang, S., Fang, Y.-Z., Lupton, J. R. & Turner, N. D. Glutathione Metabolism and Its Implications for Health. The Journal of Nutrition 134, 489–492 (2004).
3. Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC. Mitochondrial glutathione, a key survival antioxidant. Antioxid Redox Signal.11(11):2685–2700, (2009)
4. Pompella, A., Visvikis, A., Paolicchi, A., Tata, V. D. & Casini, A. F. The changing faces of glutathione, a cellular protagonist. Biochemical Pharmacology 66, 1499–1503 (2003).5. Bray, T. M. & Taylor, C. G. Tissue glutathione, nutrition, and oxidative stress. Canadian Journal of Physiology and Pharmacology 71, 746–751 (1993).
6. Teixeira FK, Menezes-Benavente L, Galvão VC, Margis-Pinheiro M. Multigene families encode the major enzymes of antioxidant metabolism in Eucalyptus grandis L. Genet Mol Biol. 28(3):529–538 (2005).
7. Wang, W. & Ballatori, N. Endogenous Glutathione Conjugates: Occurrence and Biological Functions. Pharmacological Reviews 50, 335–355 (1998).
8. Aoi, W. et al. Glutathione supplementation suppresses muscle fatigue induced by prolonged exercise via improved aerobic metabolism. Journal of the International Society of Sports Nutrition 12, (2015).
10. Duperray, J., Perin, F., Tachalerdmanee, P., Chalothorn, K. & Sergheraert, R. The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial. Journal of Cosmetic Dermatology 21, 802–813 (2021).
9. Bailey, C. P., Figueroa, M., Gangadharan, A., Lee, D. A. & Chandra, J. Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Frontiers in Immunology 11, (2020).
10. Weschawalit, S., Phutrakool, P., Thongthip, S. & Asawanonda, P. Glutathione and its antiaging and antimelanogenic effects. Clinical, Cosmetic and Investigational Dermatology 10, 147–153 (2017).
11. Duperray, J., Perin, F., Tachalerdmanee, P., Chalothorn, K. & Sergheraert, R. The effects of the oral supplementation of L-Cystine associated with reduced L-Glutathione-GSH on human skin pigmentation: a randomized, double-blinded, benchmark- and placebo-controlled clinical trial. Journal of Cosmetic Dermatology 21, 802–813 (2021).
12. Sinha, R. et al. Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. European journal of clinical nutrition 72, 105–111 (2017).
13. Wang, Y. et al. SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature 599, 136–140 (2021).
14. Kumar, P., Osahon, O. W. & Sekhar, R. V. GlyNAC (Glycine and N-Acetylcysteine) Supplementation in Mice Increases Length of Life by Correcting Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Abnormalities in Mitophagy and Nutrient Sensing, and Genomic Damage. Nutrients 14, 1114 (2022).
15. Nagapan, T. S., Basri, D. F., Ghazali, A. R. & Lim, W. N. Oral supplementation of L-glutathione prevents ultraviolet B-induced melanogenesis and oxidative stress in BALB/c mice. Experimental Animals 68, 541–548 (2019).
16. Hara, Y., Mckeehan, N., Dacks, P. A. & Fillit, H. M. Evaluation of the Neuroprotective Potential of N-Acetylcysteine for Prevention and Treatment of Cognitive Aging and Dementia. The Journal of Prevention of Alzheimer’s Disease 4, 1–6 (2017).
17. Dröge, W. & Breitkreutz, R. Glutathione and immune function. Proceedings of the Nutrition Society 59, 595–600 (2000).
18. To, K. et al. Effects of Oral Liposomal Glutathione in Altering the Immune Responses Against Mycobacterium tuberculosis and the Mycobacterium bovis BCG Strain in Individuals With Type 2 Diabetes. Frontiers in Cellular and Infection Microbiology 11, (2021).19. Kwiatkowska, D. Effects of Supplementation with Glutathione and its Precursors on Athlete Performance. Biomedical Journal of Scientific & Technical Research 12, (2019).