Healthy sleep is fundamental to comprehensive wellness. The essential nature of your sleep can be well-summarized in the following
statistic: On average you spend approximately one-third of your life asleep. But sleep is not a singular thing. Quality of rest, sleep-wake cycle, and circadian rhythm are part of a complex web of external factors, bodily systems, and biochemical processes that affect your sleep. Imbalances (or disturbances) to these can result in sleep disorders, which can negatively affect your quality of life in many ways. And while the amount of sleep required varies from person to person, healthy sleep is vital for everyone.
But what exactly is sleep?
Your sleep is a dynamic, multistage process which “cycles” several times on a typical night. Throughout these sleep stages, cells rejuvenate, tissues are restored, and the brain’s plasticity is renewed. A biological clock in your brain controls circadian rhythm to promote quality rest. Sleep disorders affect all ages, and as you get older these become even more common. As you age, your melatonin production declines. However, external factors like stress, excessive alcohol use, overuse of artificial light at night, and inconsistent sleep habits can cause numerous sleep issues.
nox super sleep is professionally formulated to work with the body and its natural processes by promoting mitochondrial function, calm restlessness, aid the metabolic function of melatonin synthesis and support the regulation of the natural sleep-wake cycle. Nox super sleep contains a number of carefully formulated and efficacious naturally occurring sleep support ingredients.
Unlike other sleep formulas, we have created a holistic and broad multi-ingredient sleep strategy:
- GABA and L-Theanine reduce neural excitability*
- Melatonin and 5-HTP regulate sleep-wake cycles*
- A special herbal extract combination alleviates pre-sleep anxiety*
- Inositol, Pyridoxyl-5-Phosphate, and L-Glycine support underlying metabolic and neurotransmitter balance*
This synergistic interplay provides the most effective sleep support product available today.
Liquid delivery allows for a convenient, more direct route, and customized dosage to fit your sleep needs. Much better and gentler than taking a sleeping pill – no bad stomach effects. The real citrus oils in nox provide a complementary flavor and fragrance organoleptic experience, while the active sleep ingredients do their job. Most other products claim “natural flavors and fragrances” without saying what they really are, and there have been court cases about what is really natural. Our sugar free formula eliminates extra nighttime calories and the opportunity for dental cavities common with gummy consumption. This couldn’t be better! Even more, our packaging includes BPA free ultraviolet glass for superior product preservation, as well as FSC mix box material and soy-based inks to help protect forests and promote sustainable practices in the packaging industry.
It's not just sleep. It’s Super Sleep.
* The Food and Drug Administration has not evaluated this product and its claims and therefore the information contained herein is not intended to diagnose, treat, cure, or prevent any disease.
Adults take one serving (7 pumps) before bed or as directed by your healthcare professional. Avoid contact with pump dispenser to preserve freshness. Store in a cool dry place away from direct sunlight. Do not use if tamper- evident packaging is broken or missing. Shake well before use.
The Science of Natural Sleep Supplements: Mechanisms, Efficacy, and Safety*
Our scientists have developed a comprehensive scientific analysis which explores the mechanisms, efficacy, and safety of inositol, GABA, melatonin, L-theanine, pyridoxyl-5-phosphate, L-glycine, 5-hydroxytryptophan, lavender flower extract, passion flower extract, and chamomile extract . This analysis synthesizes current research findings, highlighting the role of each supplement in enhancing sleep, its physiological mechanisms, and its effectiveness.. By examining the interplay between these compounds and sleep-related neurochemical pathways, circadian rhythms, and sleep architecture, this research provides valuable insights into how nox sleep has been formulated to improve your sleep quality and addresses various sleep disorders keeping you awake at night and preventing you from having a restful, peaceful sleep.
The figure below summarizes the science of these ingredients:
Inositol: Its Role in Sleep Regulation
Inositol has been studied for sleep enhancement. Inositol is known for its involvement in physiological processes, including signal transduction and ion-channel permeability, which are critical for neurotransmitter activity and hormone signaling in sleep-wake cycles. Inositol phosphate acts as a secondary messenger, influencing sleep-related processes. Myo-inositol’s significance in neuronal function and brain health is of importance, with lower levels associated with sleep disturbances and depressive symptoms in adolescents (1), making it a biomarker for sleep quality. Interactions with neurochemical pathways, including glutamatergic function and circadian rhythms (2, 3, 4) and orexin pathways (5), underscore its role in sleep architecture. Its effect on sleep is related to its alleviation of anxiety and depression* (6). Inositol’s mechanism involves phosphorylation cascades and calcium signaling that affect slow-wave sleep. (7, 8) Inositol also benefits your metabolic health and circadian rhythm. (9, 10, 11)
GABA: An Inhibitory Neurotransmitter for Sleep Improvement
GABA, the primary inhibitory neurotransmitter, has been scientifically studied for its role in sleep enhancement, with supplementation showing promise in reducing sleep latency and enhancing non-REM sleep quality. Its Mechanism of action involves GABA receptors, specifically GABAA and GABAB, which modulate inhibitory synaptic transmission by enhancing chloride influx, reducing neuronal excitability, and fostering a sedative state. (12, 13) Caffeine is known to reduce levels of GABA and block its receptors. This causes arousal and alertness which reduces your sleep. (14) Human studies with GABA have shown a decreased latency, meaning less time to fall asleep (15). Other studies have shown the oral efficacy of consuming GABA to improve sleep. (16) GABA synergy with L-Theanine significantly reduces latency and increases REM/NREM sleep (17), with clinical trials reporting improved subjective quality and next-day cognition. (18, 19) GABA safety has been established (20, 21, 22), highlighting its use as a supplement ingredient.
Melatonin: A Circadian Rhythm Regulator for Sleep
Melatonin is the sleep hormone. Its’ role in sleep enhancement is well-documented; it regulates circadian rhythms and promotes sleep onset/maintenance without altering sleep architecture. Low-dose treatment advances or delays the circadian clock phase, which is beneficial for insomnia and rhythm disorders. (23, 24) It has also been shown to be effective for chronic insomnia, and for sleep issues associated with rheumatoid arthritis, autism, and cancer patients*. (25, 26, 27, 28) Children with neurodevelopmental disorders exhibit improved initiation and duration* (29, 30), with mechanisms that involve phase-shifting and evolutionary conservation. (31) Dosage ranges from 1 to 10 mg, with 3 mg being an optimal dose. (28, 30, 32, 33) However, the sustaining sleep effects of melatonin are less clear. (34, 35) Short and long-term usage in adults is well tolerated, without significant adverse effects (36, 37), while long-term usage in adolescents may involve puberty disruption. (38, 39)
L-Theanine: The Relaxation Promoter for Sleep
L-Theanine is a special amino acid that enhances sleep through its anxiolytic effects, reducing stress and promoting relaxation via alpha brain wave induction. It elevates GABA levels through mechanisms that modulate GABAergic activity, thereby decreasing pre-sleep anxiety. (40, 41, 42) It improves satisfaction and reduces disturbances in MDD/GAD (43), but less so in ADHD (44), with PSQI scores lowered for latency and disturbance. (45) All of this means that L-theanine works better in people with anxiety and depression disorders, but less so in kids with ADHD. Synergy of L-theanine with GABA increases REM/non-REM sleep. (17) From a safety perspective, no significant adverse long-term effects over extended periods support its safety for extended use. (40, 41) Overall, the existing scientific literature supports L-theanine as a safe alternative for improving sleep quality in various populations, including those suffering from anxiety or sleep disturbances. (46, 47)
Pyridoxyl-5-phosphate: A Promising Sleep Link
Pyridoxyl-5-phosphate (P5P), vitamin B6’s active form, acts as a cofactor for serotonin/GABA synthesis, which is crucial for sleep cycles. (48) Deficiencies are linked to disrupted patterns (48), with potential benefits for chronic issues (49, 50), and support for the circadian rhythm through boosting serotonin levels. (51) Mechanisms of how P5P works involve metabolic/neurochemical pathways, with parallels to vitamin D (49, 50, 52, 53, 54). (50, 53, 54) P5P is generally recognized as safe for human consumption, displaying minimal side effects. (55) Novel vitamin B6 toxicity has been noted in a rare case of pyridox(am)ine-5-phosphate oxidase deficiency, an inborn error of vitamin B6 metabolism. (56) Consuming P5P will help address this deficiency.
L-Glycine: The Sleep Quality Enhancer
L-Glycine improves sleep quality, reducing awakenings and enhancing next-day cognition, especially in active individuals. It acts as an inhibitory neurotransmitter, modulating NMDA receptors and decreasing body temperature, facilitating the onset of sleep. (57, 58) Polysomnography studies show sleep benefits and safety of L-Glycine. (57, 58, 59, 60, 61) It increases NREM sleep, and works well in older adults (60, 61). L-Glycine has potential synergy with protein diets (62, 63), making for a feasible and safe supplement.
5-Hydroxytryptophan (5-HTP): The REM Sleep Booster
5-Hydroxytryptophan (5-HTP), is a serotonin precursor that is convertible to melatonin. It enhances REM sleep and quality. It works through the serotonergic and GABAergic pathways. (64, 65) Meloni et al. (2021) demonstrated benefits for sleep in Parkinson’s patients,* by increasing REM sleep without exacerbating REM sleep behavior disorder (RBD), and also by reducing wake time. (66) within some cases daytime administration has been shown to enhance non-REM sleep. (67) 5-HTP is generally considered safe for both short-term and long-term use, with minimal side effects reported in various clinical studies. The safety of 5-HTP, particularly in the context of depression treatment, has been highlighted in studies with doses ranging from 20 to 3,250 mg per day. (68) Furthermore, 5-HTP has been linked to improved sleep patterns by enhancing melatonin synthesis, which is crucial for regulating sleep-wake cycles. (69) Additionally, the chronic use of 5-HTP does not seem to increase the risk of serotonin syndrome, particularly when used cautiously. (70) All the scientific evidence tells us that 5-HTP is a useful natural remedy for sleep issues, with established safety and effectiveness. (71)
Lavender Flower Extract: A Targeted Sleep Aid
Lavender flower extract enhances sleep, particularly in postmenopausal women and the elderly It does this via GABA modulation, promoting relaxation. (20) A dose of 500 mg has been shown to improve sleep quality (72), with systematic reviews noting its safety for mild insomnia. (73) Its’ efficacy is supported in cardiac patients (74), with benefits from aromatherapy (75); however, some studies show lesser effects. (76) Lavender flower extract is a safe and effective option for sleep treatment. (77, 78)
Passion Flower Extract: Anxiolytic Sleep Support
Passion Flower extract reduces sleep latency and improves sleep quality through GABA modulation, and it has anxiolytic (anxiety) effects. (20) Additionally, it has a prolonged stress reduction effect, benefiting users in both wake and sleep states. (79, 80) Its’ efficacy compares to oxazepam with fewer side effects* (81), but chemical variability in the marketplace poses challenges. (82) Safety is good (83), with potential synergies (73, 84), providing for a natural alternative.
Chamomile Extract: Multiple Sleep Benefits
Chamomile extract exhibits mixed results, with sedative effects attributed to apigenin’s interaction with GABA receptors (85, 86). Studies have shown reduced latency (87), with human benefits in postpartum women (88), but modest gains for chronic insomnia. (89) Mechanisms involve melatonin modulation for mild issues. (90, 91) Chamomile extracts are generally considered safe and are suitable for addressing mild sleep issues. (85, 92)
Conclusion: Synergistic Effects
The combination of Inositol, GABA, Melatonin, L-Theanine, Pyridoxyl-5-Phosphate, L-Glycine, 5-Hydroxytryptophan (5-HTP), Lavender Flower Extract, Passion Flower Extract, and Chamomile Extract offers a multifaceted approach to enhancing sleep quality by targeting neurotransmitter regulation, circadian rhythm modulation, and anxiety reduction. Research suggests these supplements work synergistically, with GABA and L-Theanine notably reducing sleep latency by 14.9–20.7% and increasing sleep duration by 26.8–87.3%, boosting REM and non-REM sleep through enhanced GABA and glutamate receptor activity. (17) Melatonin, a regulator of the circadian rhythm, complements 5-HTP, a precursor to serotonin and melatonin, enhancing sleep onset and quality; however, caution is advised due to the rare risks of serotonin syndrome when combined with serotonergic agents. (25, 71) Herbal extracts, including lavender, Passionflower, and chamomile, modulate GABAergic pathways, thus reducing anxiety and promoting relaxation. Systematic scientific reviews have indicated better outcomes when these ingredients are used in combination than when used individually. (73) Lavender’s efficacy in postmenopausal women and chamomile’s sedative effects, attributed to apigenin, highlight their roles in alleviating mild insomnia. (72, 85) Passion Flower’s anxiolytic properties, comparable to oxazepam,* further support sleep initiation. (81) Inositol and Pyridoxyl-5-Phosphate contribute indirectly by supporting serotonin and GABA synthesis, potentially stabilizing neurochemical pathways crucial for sleep. (1, 48) L-Glycine enhances sleep quality by reducing awakenings and lowering body temperature, with benefits in active individuals. (59)
The interplay of these compounds provides for a holistic strategy: GABA and L-Theanine reduce neural excitability, Melatonin and 5-HTP regulate sleep-wake cycles, and herbal extracts alleviate pre-sleep anxiety, while Inositol, Pyridoxyl-5-Phosphate, and L-Glycine support underlying metabolic and neurotransmitter balance.
*The Food and Drug Administration has not evaluated this scientific review and therefore the information contained herein is not intended to diagnose, treat, cure, or prevent any disease. According to the FDA, only drugs can make those claims.
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