A healthy life requires healthy cells. When cellular damage occurs, often later in life, we begin to forfeit our biological robustness. This is why we associate numerous degenerative conditions with aging. From dark spots to chronic disease, age-related symptoms are often the manifestation of oxidative stress at the cellular level.
What is oxidative stress?
Oxidative stress is a phenomenon in the body caused by a disturbance in the balance between the production of reactive oxygen species (ROS) in the cell, and the cell’s ability to detoxify these products. Sufficient antioxidants are necessary to maintain the critical equilibrium between ROS production and scavenging. ROS accumulation can result in damaged mitochondrial DNA and protein. Strong protection against oxidative stress is critical to health, wellness and vitality.
Pterostilbene (Pt) is a highly bioavailable antioxidant. As a potent polyphenol, Pt is a natural analog to Resveratrol (Rv). Like Rv, Pt has profound detoxifying properties. However, purity and bioavailability are critically important to help protect against oxidative stress. PtXPRO is the result of expert aging science, professionally formulated with PteroGEN, which is 99%+ pure trans-Pterostilbene. PtXPRO has extremely high antioxidant, anti-flammatory, anticarcinogenic and cardioprotective potential, combined with delayed release vegan capsules which are clinically proven to resist stomach acids for targeted absorption in the small intestine, providing maximum bioavailability.
PtXPRO is proudly manufactured in the USA and sold exclusively in the USA. Every batch is third-party tested to ensure professional-grade quality and purity. Our packaging includes BPA free ultraviolet glass for superior preservation, as well as FSC mix box material and soy-based inks to help protect forests and promote sustainable practices in the packaging industry.
The science of healthy aging is clear: Cell health = Your health.
Take one (1) capsule daily, without food in the morning, or as directed by your healthcare professional. Consult your healthcare professional before taking any dietary supplement, if you are pregnant, nursing, or taking any medication. Keep out of reach of children.
Store in a cool, dry place away from direct sunlight. Do not use if tamper-evident packaging is broken or missing.
Pterostilbene: A Promising Natural Compound for Health and Longevity*
Pterostilbene, a naturally occurring polyphenolic compound found in blueberries and grapes (1) and (2), has garnered significant attention in recent years, owing to its potential health benefits and therapeutic applications. This review summarizes the current understanding of the biological functions, pharmacological properties, and potential health benefits of pterostilbene.
Chemical Structure and Sources
Pterostilbene is a dimethylated analog of resveratrol, which contains two methoxy groups and one hydroxyl group. (3) This structural difference contributes to its enhanced lipophilicity, membrane permeability, and bioavailability compared to resveratrol. (3) Pterostilbene is primarily found in blueberries, grapes, and some medicinal plants. (3, 4)
Biological Functions and Mechanisms
Pterostilbene exhibits a wide range of biological functions, including antioxidant, anti-inflammatory, anticarcinogenic, and neuroprotective properties.* (5, 2, 6) Its primary mechanism of action involves the modulation of multiple signaling pathways related to oxidative stress, inflammation, and cellular senescence. (7, 8)
Health Benefits
Potential Cancer Prevention and Therapy*: Pterostilbene has shown promising anticancer prospects effects against various cancer types, including the inhibition of 9. It inhibits tumor growth, metastasis, and angiogenesis; promotinges apoptosis; and enhancing immunotherapy.* (9) Interestingly, pterostilbene exhibits contrasting effects on normal and cancer cells, acting as an antioxidant in normal cells while generating oxidative stress in cancer cells.* (10)
Cardiovascular Health: Studies have demonstrated the ability of pterostilbene to reduce plasma cholesterol, improve lipid profiles, and attenuate vascular diseases.* (2, 11) Its antioxidant and anti-inflammatory properties significantly contribute to cardiovascular benefits.* (2, 12)
Liver Health: Pterostilbene has shown hepatoprotective effects, including alleviation of liver fibrosis, reduction of hepatic steatosis, and improvement of overall liver function.* (13, 14) It modulates key hepatic enzymes involved in glucose metabolism and exhibits antioxidant properties by reducing hepatic TBARS levels and increasing SOD and GSH levels. (15)
Diabetes Management*: Pterostilbene administration decreases plasma glucose levels, increases insulin levels, and improves insulin sensitivity in diabetic animal models.* (16, 15) These effects are mediated in part by the activation of Nrf2, a master regulator of antioxidant genes. (17)
Neuroprotection: The ability of pterostilbene to cross the blood-brain barrier due to its low molecular weight and good fat liposolubility contributes to its neuroprotective effects. (6) It has shown potential in addressing neurodegenerative conditions, such as Alzheimer's disease.* (11)
Mitochondrial Health: Pterostilbene demonstrates significant protective effects on mitochondrial health, particularly in the context of oxidative stress-induced damage. (18) It facilitates mitochondrial biogenesis and increases the activity of the mitochondrial complexes18complexes. (18)
Safety and Clinical Trials
A randomized double-blind placebo-controlled trial evaluated the safety of long-term pterostilbene administration in humans with hypercholesterolemia. (19) This study found that pterostilbene was generally safe for use in humans at doses up to 250 mg/day, with no adverse drug reactions to hepatic, renal, or glucose markers. (19)
However, it is important to note that while pterostilbene shows promise in preclinical studies, its efficacy in human trials for conditions such as dementia has been less conclusive. (20) More extensive clinical trials are needed to fully evaluate its therapeutic potential across various health conditions.
Longevity and Aging
Pterostilbene, along with resveratrol, has shown potential in modulating various hallmarks of aging, including oxidative damage, inflammation, telomere attrition, and cell senescence. (8) These effects suggest that pterostilbene may play a role in promoting longevity and healthy aging. However, most research in this area has been conducted on cellular models or animal studies, highlighting the need for more human clinical trials to establish its direct effects on human longevity. (21, 22)
Conclusion
Pterostilbene is a promising natural compound with diverse biological functions and health benefits. Its superior bioavailability, reduced toxicity, and enhanced stability compared to resveratrol make it an attractive candidate for various biomedical applications. (23, 24) From cancer prevention to cardiovascular health, diabetes management, and neuroprotection, pterostilbene has a wide range of therapeutic potential.*
As research progresses, pterostilbene may play an increasingly important role in preventive medicine and management of various chronic diseases.* Future research should focus on conducting rigorous clinical trials, optimizing pterostilbene formulations to enhance bioavailability, and exploring potential synergistic effects with other compounds. With our understanding of pterostilbene’s mechanisms and effects in humans, it may become a valuable tool in our quest for better health and longevity.
*This literature review has not been evaluated by the Food and Drug Administration, and therefore the information contained herein is not intended to diagnose, treat, cure, or prevent any disease. According to the FDA, only drugs can make those claims.
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