Our cells are the foundation of health and wellness. Disrupting cellular homeostasis can result in cellular injury, even death of the cell. When cellular damage occurs, every organ and tissue is at risk. This is common later in life. Aging is typically associated with numerous degenerative conditions. The battle to slow these symptoms of aging is waged at the cellular level, and healthy cells require the expression of a wide range of antioxidant enzymes to support proper mitochondrial function.
Why are antioxidants important?—and what are mitochondria?
Healthy cells require the correct balance between the production of reactive oxygen species (ROS) and antioxidants. Mitochondria are self-replicating, subcellular organelles, responsible for both the production of most of the energy and ROS in cells. Insufficient antioxidants lead to ROS accumulation, causing damage to mitochondrial DNA and protein. This oxidation—called oxidative stress—is precisely why antioxidants and the modulation of their cellular pathways are critically important. Antioxidants are the frontline warriors in the fight to maintain equilibrium between ROS production and scavenging, also known as mitochondrial redox (oxidation reduction) homeostasis.
Resveratrol (Rv) is a biologically active compound with a wide range of functions. Importantly, as a dynamic phytoalexin metabolite, Rv has strong protective properties to fortify the modulation of cellular antioxidant pathways to maintain the balance of cellular redox status. RvXPRO is the result of expert aging science, professionally formulated with ResveraGEN, which is 99%+ pure trans-Resveratrol. RvXPRO has extremely high antioxidant, anti-inflammatory, anticarcinogenic and cardioprotective potential, combined with delayed release vegan capsules which are clinically proven to resist stomach acids for targeted absorption in the small intestine, providing maximum bioavailability.
RvXPRO is proudly manufactured in the USA and sold exclusively in the USA. Every batch is third-party tested to ensure professional grade quality and purity. Our packaging includes BPA free ultraviolet glass for superior preservation, as well as FSC mix box material and soy-based inks to help protect forests and promote sustainable practices in the packaging industry.
The science of healthy aging clear: Cell health = Your health.
Take one (1) capsule daily, without food in the morning, or as directed by your healthcare professional. Consult your healthcare professional before taking any dietary supplement, if you are pregnant, nursing, or taking any medication. Keep out of reach of children.
Store in a cool, dry place away from direct sunlight. Do not use if tamper-evident packaging is broken or missing.
Resveratrol: Its Multifaceted Health Benefits and Therapeutic Potential*
Resveratrol, a naturally occurring compound found in various plants, particularly in the skin of red grapes, peanuts, and berries, has gained significant attention because of its diverse health benefits and potential therapeutic applications. (1, 2) This review aims to explore the current understanding of the biological activities of resveratrol, its mechanisms of action, and potential clinical applications, as well as the challenges and future directions of resveratrol research.
Chemical Structure and Sources
Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a stilbenoid compound that exists in two isomeric forms: cis-resveratrol and trans-resveratrol, with the trans form being more stable and biologically active. (2, 3) The compound’s chemical structure consists of two phenol rings connected by a double styrene bond, which contributes to its unique properties and biological activities. (4) Primary dietary sources include red wine, grape juice, peanuts, blueberries, and cranberries. (2, 3) The concentration of resveratrol in these sources can vary significantly depending on factors such as plant variety, growing conditions, and processing methods. (5)
Biological Activities and Mechanisms of Action
Resveratrol exhibits a wide range of biological functions, including antioxidant, anti-inflammatory, anti-carcinogenic, and neuroprotective potential.* (2, 6, 7) Its mechanism of action involves modulating diverse targets and signaling pathways, affecting all three stages of carcinogenesis: initiation, promotion, and progression.* (8, 9)
Antioxidant Properties: The compound’s antioxidant properties are particularly noteworthy, as it acts as a potent antioxidant and anti-inflammatory agent that protects cells from oxidative stress. (10, 6) Resveratrol can directly scavenge free radicals that are harmful to DNA, and enhance the expression of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase which eliminate free radicals. (11)
Anti-inflammatory Effects*: Resveratrol exerts its anti-inflammatory effects by inhibiting pro-inflammatory mediators and modulating inflammatory signaling pathways. (12) It has been shown to suppress the activation of nuclear factor-κB (NF-κB), a key transcription factor involved in inflammation. (13) Inflammation can significantly impact overall health and well-being through various detrimental effects on the body. These symptoms include tissue damage, organ dysfunction, pain, swelling, and reduced mobility. Chronic inflammation is associated with an increased risk of serious diseases such as cardiovascular problems, diabetes, and cancer.* It can also compromise the immune function, leading to fatigue, cognitive decline, and insulin resistance. Additionally, inflammation may cause joint deterioration, gastrointestinal issues, and skin conditions, and accelerate the aging process. Given these wide-ranging effects, effective management of inflammation is crucial for maintaining good health and preventing long-term complications. (14, 15, 16, 17)
Modulation of Cell Signaling: Resveratrol modulates multiple signaling pathways involved in cell survival and neuronal adaptability. (18) It activates sirtuin 1 (SIRT1), a NAD+-dependent deacetylase that plays a crucial role in cellular metabolism, stress resistance, and longevity. (19) Additionally, resveratrol influences the AMP-activated protein kinase (AMPK) pathway, which regulates energy homeostasis (energy regulation) and metabolism. (20)
Epigenetic Regulation: Recent studies have highlighted the ability of resveratrol to modulate epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs. (21) These epigenetic effects may contribute to its diverse biological activities and potential therapeutic applications. Epigenetic regulation plays a crucial role in human health and development throughout the lifespan. It is essential for normal development, cellular function, and gene expression regulation. (22) Epigenetic mechanisms are particularly important in the nervous system, regulating neuronal gene expression, DNA damage, genome stability, and higher-level cognitive behaviors such as learning and memory. (23) Interestingly, epigenetic regulation extends beyond individual development, potentially impacting future generations. Environmental stresses experienced by older generations may predispose subsequent generations to disease through the transgenerational inheritance of epigenetic information. (22) This concept is supported by epidemiological studies in humans exposed to famine, stress/trauma, or toxicants, which have shown that parental exposure can affect the health of descendants sometimes across several generations. (24)
Health Benefits and Potential Therapeutic Applications
Cardiovascular Health: Resveratrol has shown promise in improving cardiovascular health through its antioxidant and anti-inflammatory effects. (25) It has been associated with the “French Paradox,” which refers to the observation that French people have lower rates of cardiovascular disease despite consuming a high-fat diet.* (5, 26) Resveratrol’s cardioprotective effects include improving vascular health, reducing blood pressure, inhibiting platelet aggregation, and modulating lipid metabolism. (27, 28)
Neuroprotection: Studies have demonstrated resveratrol's neuroprotective properties in various neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, and Huntington's disease.* (11, 12, 21) Its ability to cross the blood-brain barrier and influence brain activity makes it a promising candidate for further research. (29) Resveratrol’s neuroprotective effects are attributed to its antioxidant and anti-inflammatory properties, as well as its ability to modulate neurotransmitter systems and the ability for the brain to adapt. (30)
Anti-carcinogenic Potential*: Resveratrol has shown potential in inhibiting proliferation of tumor cells.* (9) It induces apoptosis and inhibits proliferation, migration, and invasion of cancer cells.* (31, 32, 33) The compound’s anti-cancer effects are mediated through multiple mechanisms, including cell cycle arrest (stops the cell from dividing), induction of apoptosis (cell death), inhibition of angiogenesis (formation of blood vessles), and modulation of epigenetic factors.* (34) Resveratrol has shown promising results in various cancer types, including breast, colon, prostate, and lung cancers (35), yet further research is needed to understand its potential as an anti-carcinogen.*
Metabolic Health: Research has indicated potential benefits of resveratrol in improving metabolic health, including effects on diabetes and obesity. (7, 36) Resveratrol has been shown to improve insulin sensitivity, reduce blood glucose levels, and enhance mitochondrial function. (37) In obesity, resveratrol may help reduce adipogenesis (fat cell formation), promote fat breakdown, and modulate adipokine (fat cell) production. (38)
Longevity and Anti-aging: While some studies suggest potential anti-aging properties of resveratrol, its effects on mammalian lifespan remain inconclusive. (39, 40, 41) Resveratrol’s ability to activate SIRT1 and mimic calorie restriction has sparked interest in its potential to promote longevity. (42) However, translation of these effects from animal models to humans requires further investigation.
Skin Health: Emerging research suggests that resveratrol may have beneficial effects on skin health and aging. (43) Its antioxidant and anti-inflammatory properties may help protect the skin from UV-induced damage, reduce wrinkle formation, and improve skin elasticity. (44)
Conclusion
Resveratrol is a versatile compound with a wide range of biological activities and potential therapeutic applications. Its antioxidant, anti-inflammatory, and modulatory effects on various signaling pathways make it a promising candidate for the prevention and treatment of numerous health conditions. While preclinical evidence is promising, further research is needed to overcome challenges related to bioavailability, as well as establish the full range of its efficacy in clinical settings. As our understanding of resveratrol’s mechanisms of action and pharmacokinetics continues to grow, it may pave the way for novel therapeutic strategies for the management of chronic diseases and the promotion of healthy aging.
*This literature review has not been evaluated by the Food and Drug Administration, and therefore the information contained herein is not intended to diagnose, treat, cure, or prevent any disease. According to the FDA, only drugs can make those claims.
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